Estradiol (E2) is the most potent and predominant form of estrogen in the body, playing a crucial role in reproductive health, bone density, and cardiovascular function in both women and men.
Estradiol is the primary estrogen hormone produced mainly by the ovaries in women and in smaller amounts by the testes in men and adrenal glands in both sexes. It's essential for reproductive function, bone health, brain function, and cardiovascular protection.
In women, estradiol levels fluctuate throughout the menstrual cycle, peaking just before ovulation. It's responsible for the development of secondary sexual characteristics, regulating the menstrual cycle, and maintaining pregnancy. During menopause, estradiol levels decline significantly, leading to symptoms like hot flashes and bone loss.
In men, estradiol is important for bone health, brain function, and libido. However, elevated levels can cause gynecomastia (breast enlargement) and other feminizing effects.
Testing estradiol helps evaluate fertility issues, menstrual irregularities, menopause status, hormone therapy effectiveness, and hormonal imbalances in both sexes.
Price
$12
Results
1-2 days
Lab Network
Quest
Fasting
Not Required
What's Measured
What This Test Measures
This test measures estradiol (E2) concentration in pg/mL. Normal ranges vary significantly based on sex, age, and menstrual cycle phase in women. Premenopausal women range from 30-400 pg/mL depending on cycle day, postmenopausal women typically below 30 pg/mL, and men usually 10-40 pg/mL.
Who Should Consider This Test
Women experiencing menstrual irregularities or infertility, women in perimenopause or menopause, women on hormone replacement therapy, men with gynecomastia or low libido, anyone evaluating hormonal imbalances, couples undergoing fertility treatment.
Health Insights
Conditions Screened
Related Symptoms
When to Get Tested
No fasting required. For menstruating women, timing matters: test on days 2-5 for baseline or day 12-14 to assess ovulation. For fertility treatment, follow your provider's instructions. Postmenopausal women and men can test anytime.
Understanding Your Results
Results depend on your sex and situation. Premenopausal women see wide variations (30-400 pg/mL) based on cycle phase. Postmenopausal women typically have levels below 30 pg/mL. Men normally range 10-40 pg/mL. Elevated or low levels have different implications requiring clinical interpretation.
What to Expect
After placing your order, you'll receive an email from Rupa Health (our lab order partner) within 24 business hours to sign a consent form and schedule your blood draw at a Quest Diagnostics location.
The blood draw typically takes just a few minutes. Results are usually available within 1-2 business days and will appear in your secure Justlabs dashboard.
Our results include reference ranges and easy-to-understand indicators showing whether your values are within normal limits.
Frequently Asked Questions
$12
Typical hospital cash price: $120–$180
+ $28 in standard lab & physician fees at checkout (no additional bills later)
$18 lab collection + $10 physician order
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