Low estradiol can indicate ovarian insufficiency, perimenopause/menopause, extreme exercise or low body weight, or pituitary problems.

High estradiol outside of expected cycle peaks can suggest PCOS, estrogen-producing tumors, liver disease, or obesity (fat tissue produces estrogen).

For baseline/fertility: cycle day 2-5. For ovulation confirmation: mid-cycle. For perimenopause: any time, as the cycle is already disrupted.

Question 1

What is a normal estradiol level?

Accepted Answer

It varies dramatically by cycle phase: early follicular 30-100 pg/mL, ovulatory peak 100-400 pg/mL, luteal 50-200 pg/mL, postmenopausal <30 pg/mL.

Question 2

What does low estradiol mean?

Accepted Answer

Low estradiol can indicate ovarian insufficiency, perimenopause/menopause, extreme exercise or low body weight, or pituitary problems.

Question 3

What does high estradiol mean?

Accepted Answer

High estradiol outside of expected cycle peaks can suggest PCOS, estrogen-producing tumors, liver disease, or obesity (fat tissue produces estrogen).

Question 4

When in my cycle should I test estradiol?

Accepted Answer

For baseline/fertility: cycle day 2-5. For ovulation confirmation: mid-cycle. For perimenopause: any time, as the cycle is already disrupted.

Marker	Low	Normal	High
Estradiol (Premenopausal)	Below 30 pg/mL — low estrogen	30–400 pg/mL (varies by cycle phase)	Above 400 pg/mL — mid-cycle peak or supplementation
Estradiol (Postmenopausal)	N/A	<30 pg/mL (expected)	Above 30 pg/mL — possible HRT or other source

What Is a Normal Estradiol Level?

Reference Range Table