High TPO Antibodies: What It Means and What to Do Next
High TPO antibodies (above 35 IU/mL) mean your immune system is attacking your thyroid — a hallmark of Hashimoto's thyroiditis, the leading cause of hypothyroidism. Elevated TPO antibodies signal autoimmune thyroid disease even if your TSH is currently normal.
What Causes High TPO Antibodies?
Hashimoto's Thyroiditis
The most common cause. Autoimmune destruction of thyroid tissue leads to gradual hypothyroidism over months to years.
Graves' Disease
Some patients with Graves' disease also have elevated TPO antibodies alongside thyroid-stimulating antibodies.
Postpartum Thyroiditis
Autoimmune thyroid inflammation occurring in the first year after pregnancy. Usually temporary but may recur.
Family Predisposition
Autoimmune thyroid disease runs in families. Having a first-degree relative with thyroid disease increases your risk significantly.
Associated Symptoms
What to Do Next
1. Retest to confirm
A single abnormal result should be confirmed with a repeat test. Temporary factors like stress, illness, or medications can affect results.
2. Related tests to consider
3. When to see a doctor
If your TPO Antibodies is significantly abnormal, if you have severe symptoms, or if repeated results confirm the abnormality, consult a healthcare professional for appropriate evaluation and treatment.
Related Conditions
Frequently Asked Questions
Related Articles
This page is for informational purposes only and does not constitute medical advice. Consult a healthcare provider for interpretation of your results.
Content reviewed for accuracy by the JustLabs editorial team.