The ApoE genotype test identifies which variants of the ApoE gene you carry, providing insight into your genetic risk for heart disease and Alzheimer's.
Apolipoprotein E (ApoE) is a protein crucial for cholesterol transport and brain health. There are three common variants: E2, E3, and E4. Everyone inherits two copies (one from each parent), creating genotypes like E3/E3 (most common), E3/E4, or E4/E4.
The E4 variant is associated with higher LDL cholesterol, increased cardiovascular risk, and significantly elevated Alzheimer's risk. The E2 variant may offer some protection against heart disease but is associated with a rare lipid disorder. This one-time genetic test provides lifelong information about your genetic predisposition.
Price
$111
Results
5-7 days
Lab Network
Quest
Fasting
Not Required
What's Measured
What This Test Measures
This genetic test identifies your ApoE genotype - which two ApoE alleles (E2, E3, or E4) you carry. Results are permanent and never change. About 25% of people carry at least one E4 allele.
Who Should Consider This Test
Anyone wanting to understand their genetic risk for cardiovascular disease or Alzheimer's. Particularly valuable for those with family history of early heart disease or dementia, people with high LDL despite lifestyle changes, or those who want personalized prevention strategies.
Health Insights
Conditions Screened
Related Symptoms
When to Get Tested
No fasting required. This is a one-time test - your genotype never changes. Consider testing if you want genetic insight into your cardiovascular and cognitive health risks.
Understanding Your Results
E3/E3 (most common): average risk. E3/E4 or E4/E4: increased cardiovascular and Alzheimer's risk - more aggressive prevention recommended. E2/E3: may have lower cardiovascular risk. E2/E2: rare, associated with Type III hyperlipoproteinemia. Having E4 doesn't mean you'll develop disease, and not having it doesn't guarantee you won't.
What to Expect
After placing your order, you'll receive an email from Rupa Health (our lab order partner) within 24 business hours to sign a consent form and schedule your blood draw at a Quest Diagnostics location.
The blood draw typically takes just a few minutes. Results are usually available within 5-7 business days and will appear in your secure Justlabs dashboard.
Our results include reference ranges and easy-to-understand indicators showing whether your values are within normal limits.
Frequently Asked Questions
$111
Typical hospital cash price: $200–$400
+ $28 in standard lab & physician fees at checkout (no additional bills later)
$18 lab collection + $10 physician order
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